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Optimising Bioprocessing with the Terracon™ BagTote™

19 June, 2025 | ChargePoint Technology

A Comprehensive Solution for Single-Use Liquid Bag Handling.

The shift towards single-use systems has revolutionised Biopharmaceutical production processes, offering flexibility and reducing the risk of cross contamination. However, handling large volumes of liquid in 3D single-use bags presents its own set of challenges. That’s where the Terracon™ BagTote™ come in, a purpose-built solution designed to streamline the storage, handling, and transfer of single-use liquid bags.

 

The Evolution of Single-Use Systems in Biopharma

The adoption of single-use systems in biopharmaceutical manufacturing has been driven by several factors:

  • Flexibility and Scalability: Single-use systems allow for rapid scale-up and adaptation to changing production needs without the need for extensive cleaning and validation processes associated with traditional stainless-steel equipment.
  • Reduced Risk of Cross-Contamination: By using disposable components, the risk of cross-contamination between batches is significantly minimized, ensuring product purity and safety.
  • Cost Efficiency: The elimination of cleaning and sterilisation processes reduces operational costs and downtime, leading to increased productivity.

However, these benefits come with challenges, particularly in the handling and storage of large single-use bags containing up to 100L of liquid. Improper handling can lead to bag rupture, contamination, or inefficient utilisation of cleanroom space. The Terracon™ BagTote™ addresses these challenges head-on.

Design and Features of the Terracon™ BagTote™ 

The Terracon™ BagTote™ is meticulously engineered to meet the demands of modern biopharmaceutical manufacturing environments. Key design features include:

Space-Saving, Flat-Pack Design

The BagTote™ is designed for efficient use of space. Its flat-pack design allows for easy storage when not in use, and its modular construction enables multiple units to be stacked, optimizing cleanroom space utilisation. This design is particularly beneficial in facilities where space is at a premium.

Easy Assembly

Despite its robust construction, the BagTote™ is designed for easy assembly. The system can be set up by a single operator without the need for specialised tools, reducing labour costs and downtime associated with equipment setup.

Durable and Cleanable Materials

Constructed from high-quality polypropylene, the BagTote™ offers excellent chemical resistance and durability. The material is compatible with GMP cleanroom standards, ensuring that the tote can withstand the rigours of biopharmaceutical environments. Its smooth, non-porous surfaces are easy to clean, reducing the risk of contamination and ensuring compliance with stringent hygiene standards.

Hinge less Design

The hinge less design of the BagTote™ eliminates crevices where bacteria can accumulate, facilitating thorough cleaning and reducing the risk of microbial contamination. This feature is particularly important in maintaining the cleanliness of the bioprocessing environment.

Removable Front Panel

The tote features a removable front panel, allowing for quick and easy bag changes. This design enhances operational efficiency by reducing the time required to replace bags and facilitating seamless transitions between production batches.

Compatibility with Various Bag Sizes

The BagTote™ is designed to accommodate a wide range of single-use bag sizes, from 50L to 200L, and is compatible with all popular bag brands. This versatility makes it a valuable asset in facilities that handle diverse types of bioprocessing applications.

Applications of the Terracon™ BagTote™ 

The Terracon™ BagTote™ is suitable for a variety of applications in the biopharmaceutical industry:

  • Bulk Harvest and Intermediate Holding: The tote provides a secure and stable platform for holding large volumes of harvested material or intermediate products, ensuring safe storage and easy transport within the facility.
  • Product Pooling: The tote facilitates the pooling of products from multiple bags, allowing for efficient consolidation and transfer to subsequent processing stages.
  • Buffer and Media Preparation: The tote can be used to hold and mix large volumes of buffers or media, streamlining the preparation process and reducing the risk of contamination.
  • Final Formulation and Fill: The tote’s design allows for easy transfer of liquids to final formulation and fill lines, enhancing the efficiency of these critical production steps.

Benefits of Implementing the BagTote™ System 

Adopting the Terracon™ BagTote™ offers several advantages:

Enhanced Operational Efficiency

The tote’s easy assembly, compatibility with various bag sizes, and quick bag change capabilities streamline operations, reducing downtime and increasing throughput.

Improved Safety and Compliance

The tote’s durable, cleanable materials and hinge less design facilitate compliance with GMP standards, ensuring a safe and clean production environment.

Optimised Space Utilisation

The tote’s space-saving design allows for efficient use of cleanroom space, enabling facilities to accommodate more equipment and increase production capacity without the need for facility expansion.

Cost Savings

By reducing the need for specialised equipment and labour-intensive processes, the BagTote™ system contributes to cost savings in operations and maintenance.

Integration with Terracon™ Fluid Management Solutions from ChargePoint Technology.

The Terracon™ BagTote™ is part of ChargePoint Technology’s fluid management solutions, which include the Terracon™ BagTray™ System and Terracon™ TerraPure®, providing a comprehensive approach to single-use liquid handling.

Terracon™ BagTray™ System: This system offers a modular, stackable solution for holding and transferring single-use bags, complementing the BagTote™ by providing additional support and organisation.

Terracon™ TerraPure®: This product line includes polymer storage tanks designed to maintain the integrity of stored liquids, ensuring that products remain uncontaminated throughout the production process.

By integrating these solutions, facilities can achieve a streamlined, efficient, and compliant workflow for single-use liquid handling.

The Terracon™ BagTote™ represents a significant advancement in the handling and storage of single-use liquid bags in biopharmaceutical manufacturing. Its innovative design, compatibility with various bag sizes, and compliance with GMP standards make it an invaluable tool for manufacturers seeking to optimise their operations. By adopting the BagTote™ system, facilities can enhance efficiency, improve safety, and achieve cost savings, all while maintaining the highest standards of quality and compliance.

Contact our experts today for more information on the Terracon™ BagTote™ and our range of fluid management solutions.

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