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Powder Transfer Containment Valves
ChargePoint PharmaSafe® valves ensure the safer handling of Highly Potent Active Pharmaceutical Ingredients (HPAPI) and other formulation ingredients, offering the highest levels of operator protection through validated containment performance.
- Safer handling of non-sterile API and formulation ingredients
- Nanogram level containment performance
- R&D to pilot and production scale formulation
- Now with VERIFi Intelligent Monitoring Platform
Ensure industry regulatory compliance.
Process highly potent ingredients (HPAPI), ensuring the safety of your personnel and reduced environmental contamination.
Reduce risk of contamination.
Meet GMP and product quality requirements.
Maximise yield by transferring poorly flowing and high value product.
Facilitate respirator free and ‘shirt-sleeve’ manufacturing initiatives by removing costly secondary barrier containment and cumbersome PPE.
ChargePoint PharmaSafe® valve containment performance has been independently validated by customers and third parties according to the ISPE SMEPAC (Standardised Measurement of Equipment Particulate Airborne Contamination) guideline.
ChargePoint PharmaSafe® - down to 1µg/m3
High containment performance with no additional seals, vacuum or extraction required.
The entry level ChargePoint PharmaSafe® offers a simple, cost effective upgrade to facilitate the required GMP and containment requirements in manufacturing. The minimum part design is easy to operate, clean and maintain whilst providing outstanding entry level performance.
ChargePoint PharmaSafe® pro - down to 0.1µg/m3
High containment performance with a simple, low volume extraction.
The ChargePoint PharmaSafe® pro utilises an extraction process which is integral to the valve, to minimise the level of airborne contamination during the valve undocking sequence. The extraction requirement is designed to be adaptable with existing onsite air handling systems.
ChargePoint PharmaSafe® excel - <0.1 µg/m3
Advanced performance to nanogram levels in a compact efficient split valve.
The ChargePoint PharmaSafe® excel incorporates a simultaneous purge and extract sequence. During the undocking step a sealed cavity is created between the Active and Passive interface. The purge and extraction process is synchronised to remove traces of particles that can potentially become airborne once the valve is fully undocked.
Learn more about split valves and containment theory:
|The Active and Passive units are docked together. Each unit is sealed and cannot be opened unless they are docked together.|
|Two disc halves are locked in place to form a single sealed unit. The previously exposed interfaces are now sealed together to form a single butterfly valve disc.|
|The Active unit is the driving half of the valve. Once operated the disc will open to allow the transfer of material through the valve. The Active and Passive interface is sealed to ensure no material can penetrate the critical area. Once the transfer has taken place the valve is closed.|
|The Active and Passive units are then unlocked revealing the previously closed interfaces ensuring a dust free transfer.
A. Optional higher performance extraction process on PharmaSafe® pro and excel
Contained filling and dispensing for all production processes from R&D to full scale production
Filtration / Separation
Blending / Mixing
Tablets / Capsules
The ability to effectively clean or wash the product contact and sealing areas of a ChargePoint® valve is assured with the use of our specifically designed Wash In Place (WIP) devices:
• Static or penetrative type WIP devices
• Static WIP Passive offers elementary local decontamination
• Penetrative WIP Lance offers high level cleaning
• WIP Lance arrangement incorporated within Bottle Wash Stations
• WIP Active valve allows cleaning of Passive and connected IBC’s within remote wash stations
• ATEX rated designs
To learn more about cleaning & washing accessories
Lifting and docking systems can be incorporated to ensure safe operation in hazardous or inaccessible areas or where the production scale does not permit manual handling:
• Fully or partially automated versions can be provided to suit application
• Status information and sequence interlocking, secured with the use of pneumatic or electric proximity sensors
• Fully integrated and factory tested control systems
• Repeatable and safe alignment of equipment in conjunction with lifting hoists and docking systems
• Reduced weight versions
• GMP covers to protect the valve while not in use
Learn more about Handling & Docking
Wherever possible the ChargePoint® design offers the option of manual operation or partial automation versus full automation, reducing the cost and complexity of control systems. Larger diameter PharmaSafe valves can also be operated manually.
Pneumatic or electric proximity detection sensors, combined with existing mechanical safety interlock features ensure the safe function of the valve system.